Bio-nano Research

In this work we apply nanostructuring techniques to the most fundamental unit of information exchange in living systems: ion channels. Ion channels regulate the flow of ions through cell membranes, thus maintaining electrostatic activity and potential in all living systems.

Mis-functioning and non-functioning ion channels are involved in many diseases, such as immune deficiency and cardiovascular diseases. Using semiconductor materials such as glass, quartz and plastic, we have machined nanostructures that adapt to cell membranes. These 'lab on chip' devices monitor the flow of charge through ion channels and stimulate mechanically and electronically active ion channels.

Used as a test bed for high throughput screening, the 'lab on chip' creates an environment in which to observe how ion channels interact with specific drugs. The ion channel projects are being realized in collaboration with Nanion Technologies. (www.nanion.de)